Ofcin is used in diseases: Pneumonia. Chlamydia infection in the cervix or urethra with or without gonorrhea, uncomplicated gonorrhea, prostatitis. Skin and soft tissue infections. Bacterial colitis
RECIPE:
Ofloxacin ... ...................... 200 mg
Excipients q.s ... ................. 1 member
(Cassava starch, lactose, magnesium stearate, sodium starch glycolate, aerosil, PVP K30, HPMC, PEG 6000, titanium dioxide, talc).
DOSAGE FORM: Film coated tablet.
PRESENTATION: Box of 2 blisters x 10 tablets.
PHARMACOKINETICS: Ofcin with the main active ingredient is ofloxacin, quinolone antibiotic, has broad antibacterial spectrum including Enterobacteriaceae, Pseudomonas aeruginosa, Haemophilus influenzae, Neisseria spp., Staphylococcus, Streptococcus pneumoniae and some other Gram-positive bacteria . Ofloxacin has a stronger effect than ciprofloxacin against Chlamydia trachomatis, Ureaplasma urealyticum, Mycoplasma pneumoniae. Ofloxacin also works with Mycobacterium leprae, and also with Mycobacterium tuberculosis, and several other Mycobacterium spp. Ofloxacin has a bactericidal effect. Like other antibacterial quinolones, ofloxacin inhibits DNA - gyrase which is an essential enzyme in bacterial DNA replication, transcription and repair.
PHARMACOKINETICS: Ofloxacin is rapidly and well absorbed from the gastrointestinal tract. The oral bioavailability is about 100%. Absorption slows down when food is present but absorption rate is not affected. Plasma half-life is 5 - 8 hours; in the case of renal failure, the longer it depends on the degree of renal failure, then the dose needs to be adjusted. Ofloxacin is widely distributed into body fluids, including cerebrospinal fluid and well penetrates into tissues. About 25% of the drug concentration in plasma attaches to the plasma protein. The drug crosses the placenta and is secreted in breast milk. There is a relatively high concentration in bile. The kidney is the main site of ofloxacin elimination.
INDICATIONS: Ofcin is used in diseases: Pneumonia. Chlamydia infection in the cervix or urethra with or without gonorrhea, uncomplicated gonorrhea, prostatitis. Skin and soft tissue infections. Bacterial colitis.
Urinary tract infections are not complicated
Because fluoroquinolone antibiotics, including ofloxacin, are associated with serious adverse reactions (see Warnings and precautions) and uncomplicated urinary tract infections in some patients who may resolve on their own, they should only be used. ofloxacin for patients who have no alternative treatment options.
Exacerbation of bacterial infections of chronic bronchitis
Due to fluoroquinolone antibiotics, including ofloxacin, associated with serious adverse reactions (see Warnings and cautions) and acute bacterial infections of chronic bronchitis in some patients may resolve on their own, should only be Ofloxacin use for patients who have no alternative treatment options.
CONTRAINDICATIONS: Hypersensitivity to ofloxacin or other quinolones. Children under 18 years old.
WARNING AND PRECAUTIONS: Serious adverse reactions are likely not reversible and may cause disability, including tendonitis, tendon rupture, peripheral neuropathy, and adverse central nervous effects.
Fluoroquinolone antibiotics have been associated with serious and potentially irreversible adverse reactions on the various organ systems of the body. These reactions may occur simultaneously on the same patient. The most commonly reported adverse reactions include tendonitis, tendon rupture, arthralgia, myalgia, peripheral neuropathy, and adverse effects on the central nervous system (hallucinations, anxiety, depression). , insomnia, severe headache and confusion). These reactions can occur within hours to weeks after using the medication. Patients of any age or without pre-existing risk factors may experience the above adverse reactions.
Stop using the medicine at the first sign or symptom of any serious adverse reaction. In addition, avoid using fluoroquinolone antibiotics for patients who have experienced severe fluoroquinolon-related reactions.
Patients with a history of seizures or central nervous system disorders. Reduce the dose in patients with renal insufficiency.
PREGNANT WOMEN AND LACTATION: Ofloxacin should not be used during pregnancy.
Ofloxacin is excreted into human milk. If mother is forced to take ofloxacin, she must stop breastfeeding.
DRIVING AND OPERATION OF MACHINERY: Caution when driving and operating machinery.
DRUG INTERACTIONS:
Concomitant administration of ofloxacin with nonsteroidal anti-inflammatory drugs (aspirin, diclofenac, dipyron, indomethacin, paracetamol), psychotropic effect does not increase (euphoria, hysteria, psychosis). Serum ofloxacin levels may drop below therapeutic concentrations when used concomitantly with aluminum and magnesium antacids.
UNWANTED EFFECTS:
Frequent:
Gastrointestinal: Nausea, vomiting, diarrhea, abdominal pain and digestive disorders.
Neurological: Headache, dizziness, fatigue, tremor, insomnia, nightmare, visual disturbances.
Skin: Rash, itching, hypersensitivity skin reactions.
Rarely:
Neurological: hallucinations, depression, convulsions.
Skin: Vasculitis, Stevens - Johnson syndrome and toxic necrosis of the skin.
Inform your doctor unwanted effects encountered when using the drug.
OVERDOSE AND TREATMENT: In case of overdose should immediately notify the doctor.
DOSAGE AND ADMINISTRATION: Adults:
- Pneumonia: Take 2 capsules / time, 2 times a day, for 10 days.
- Chlamydia infection (in the cervix and ureter): Take 1½ capsule / time, 2 times a day, for 7 days.
- Uncomplicated gonorrhea: Take 2 tablets, a single dose.
- Prostatitis: Take 1½ capsule / time, 2 times a day, for 6 weeks.
- Skin and soft tissue infections: Take 2 capsules / time, 2 times a day, for 10 days.
- Acute bacterial infections of chronic bronchitis: Take 2 capsules / time, 2 times a day, for 10 days.
- Urinary tract infections: Cystitis caused by E. coli or K. pneumoniae: Take 1 capsule / time, 2 times a day, for 3 days.
Cystitis caused by other bacteria: Take 1 capsule / time, 2 times a day, for 7 days.
Complicated urinary tract infections: Take 1 capsule / time, 2 times a day, for 10 days.
In case of adults with impaired renal function: Creatinine clearance> 50 ml / minute: The dose does not change, take 2 times / day.
Creatinine clearance 10 - 50 ml / minute: The dose is not changed, taken 1 time / day.
Creatinine clearance <10 ml / minute: Take half dose, take 1 time / day.
Or as directed by a physician.
Read the directions carefully before use.
Expiry date: 36 months from date of manufacture.
If you need further information, please consult your doctor.
Storage conditions: Store in dry places, not exceeding 30oC, protect from light.
This drug is for a doctor's prescription.
Standard: TCCS.
Short-term treatment of upper and lower respiratory tract infections, urinary tract, skin and soft tissue, bones and joints. Klamentin has bactericidal properties against many types of bacteria including beta-lactamase-producing strains resistant to ampicillin and amoxicillin.
Spiramycin is considered to be the second choice drug for treating respiratory, skin, and genital infections caused by drug-sensitive bacteria. Prophylactic treatment of meningitis caused by Meningococcus, when there are contraindications to rifampicin. Prevention of congenital Toxoplasma infection during pregnancy. Prevention of recurrent acute rheumatoid arthritis in penicillin allergic patients.
Spiramycin is considered to be the second choice drug for treating respiratory, skin, and genital infections caused by drug-sensitive bacteria.
Acute, chronic or recurrent oral infections especially tooth abscess, gingivitis, stomatitis, periodontitis, parotid gland inflammation, inflammation of the lower jaw. Prevention of postoperative dental infections.
Treatment of prostatitis, osteomyelitis, severe bacterial enterocolitis, septicemia.
