Short-term treatment of upper and lower respiratory tract infections, urinary tract, skin and soft tissue, bones and joints. Klamentin has bactericidal properties against many types of bacteria including beta-lactamase-producing strains resistant to ampicillin and amoxicillin.
RECIPE:
Amoxicillin (in the form of amoxicillin trihydrate) ....... 500 mg
Clavulanic acid (in the form of potassium clavulanate) ......... 125 mg
Excipients q.s ... ..... 1 member
(Aerosil, polyplasdon XL, avicel M112, magnesium stearate, sepifilm LP914, titanium dioxide, talc).
DOSAGE FORM: Film coated tablet.
PRESENTATION: Box of 3 blisters x 4 tablets.
PHARMACOKINETICS: Amoxicillin is a semi-synthetic antibiotic belonging to the beta - lactam family with a broad bactericidal spectrum for many Gram positive and Gram negative bacteria due to inhibition of bacterial cell wall synthesis. But because amoxicillin is easily destroyed by beta - lactamase, amoxicillin has no effect on the bacterial strains that produce these enzymes.
Clavulanic acid has a beta-lactam structure similar to penicillin capable of inhibiting beta-lactamase produced by most Gram-negative and Staphylococcus bacteria. In particular, clavulanic acid has a strong inhibitory effect of beta - lactamases transmitted by plasmids, causing resistance to penicillins and cephalosporins. The combination of clavulanic acid and amoxicillin in Klamentin helps amoxicillin not be destroyed by beta - lactamase, while extending the antibacterial spectrum of amoxicillin effectively to many common bacteria resistant to amoxicillin and to other penicillins. and cephalosporins.
PHARMACOKINETICS: Amoxicillin and clavulanic acid are easily absorbed orally. Reaches maximum serum concentration after 1-2 hours. Absorption of the drug is not affected by food and it is best taken immediately before meals. The oral bioavailability of amoxicillin is 90% and that of clavulanic acid is 75%. The plasma elimination half-life of amoxicillin is 1-2 hours and that of clavulanic acid is about 1 hour. 55-70% of amoxicillin and 30-40% of clavulanic acid are excreted in the urine as active form. Probenecid prolongs the elimination period of amoxicillin but does not affect the elimination of clavulanic acid.
INDICATIONS: Short-term treatment of upper and lower respiratory tract infections, urinary tract, skin and soft tissue, bones and joints. Klamentin has bactericidal properties against many types of bacteria, including beta-lactamase-producing strains resistant to ampicillin and amoxicillin.
CONTRAINDICATIONS: Hypersensitivity to penicillins and cephalosporins. Severe liver failure, severe kidney failure. History of jaundice or hepatic dysfunction when using penicillin. Bacterial mononucleosis.
PRECAUTIONS: Dosage adjustment is recommended in patients with renal impairment. Prolonged treatment may cause superinfection.
PREGNANT WOMEN AND NURSING: There is no evidence of adverse effects on the fetus, but during pregnancy should be used only when clearly needed. Be careful when using the drug during breastfeeding.
DRIVING AND OPERATION OF MACHINERY: Rarely has an impact on the ability to drive and operate machines.
DRUG INTERACTIONS:
Probenecid reduces the excretion of amoxicillin in the renal tubules, thereby increasing the concentration of amoxicillin in the blood. The drug may cause prolonged bleeding and clotting time. It may reduce the effects of oral contraceptives.
UNWANTED EFFECTS:
Common: Diarrhea, vomiting, and nausea.
Uncommon: Eosinophilia. Hepatitis, cholestatic jaundice. Itching, erythema, rash
Rarely: Anaphylactic reactions, Quincke edema, thrombocytopenia, leukopenia, hemolytic anemia, pseudomembranous colitis, Stevens - Johnson syndrome. Interstitial nephritis.
Inform your doctor unwanted effects encountered when using the drug.
OVERDOSE AND DOSAGE: Overdose, the drug causes less risk of complications because it is well tolerated even at high doses. However, acute reactions depend on the individual's hypersensitivity. The risk of hyperkalemia when used in very high doses because clavulanic acid is used in the form of potassium salts. Hemodialysis can be used to remove medications from the circulation.
DOSAGE AND ADMINISTRATION: Dosage is calculated according to amoxicillin. Take the medicine right before a meal to minimize the phenomenon of intolerance to the stomach - intestines.
Adults and children over 12 years old:
For mild infections, take 1 tablet twice a day.
In severe infections, take 1 capsule 3 times / day.
In case of renal insufficiency need to adjust the dose accordingly.
Duration of treatment lasts from 5 to 10 days. Treatment should not exceed 14 days without re-examination.
Or as directed by a physician.
Read the directions carefully before use.
If you need further information, please consult your doctor.
This drug is for a doctor's prescription.
Expiry date: 24 months from date of manufacture.
Storage conditions: Store in dry places, not exceeding 30oC, protect from light.
Standard: TCCS.
Spiramycin is considered to be the second choice drug for treating respiratory, skin, and genital infections caused by drug-sensitive bacteria. Prophylactic treatment of meningitis caused by Meningococcus, when there are contraindications to rifampicin. Prevention of congenital Toxoplasma infection during pregnancy. Prevention of recurrent acute rheumatoid arthritis in penicillin allergic patients.
Spiramycin is considered to be the second choice drug for treating respiratory, skin, and genital infections caused by drug-sensitive bacteria.
Acute, chronic or recurrent oral infections especially tooth abscess, gingivitis, stomatitis, periodontitis, parotid gland inflammation, inflammation of the lower jaw. Prevention of postoperative dental infections.
Ofcin is used in diseases: Pneumonia. Chlamydia infection in the cervix or urethra with or without gonorrhea, uncomplicated gonorrhea, prostatitis. Skin and soft tissue infections. Bacterial colitis
Treatment of prostatitis, osteomyelitis, severe bacterial enterocolitis, septicemia.
