Hapacol Extra

RECIPE:

Paracetamol ... 500 mg

Caffeine ........................... 65 mg

Excipients 1 capsule

(Modified starches, avicel, wheat starch, sodium starch glycolate, erythrosin lake color, talc, magnesium stearate, strawberry flavor powder, PVP K30, sodium benzoate).

DOSAGE FORM: Tablets long.

PRESENTATION: Box of 10 blisters x 10 tablets.

ACTIONS: Hapacol Extra is a combination of Paracetamol and Caffeine:

Paracetamol is an effective analgesic - antipyretic. The drug acts on the hypothalamic heat-regulating center to cool down, increase heat dissipation due to vasodilation and increase peripheral blood flow to reduce body temperature in people with fever, but rarely with normal body temperature. At therapeutic doses, analgesic and antipyretic effects are similar to those of aspirin but Paracetamol has little effect on the cardiovascular and respiratory system, does not change the acid - base balance, does not cause irritation, scratches or stomach bleeding. . Paracetamol is rapidly and almost completely absorbed from the gastrointestinal tract. The elimination half-life is 1.25 - 3 hours. The drug is metabolized in the liver and excreted by the kidneys.

Caffeine has a mild stimulating effect on the central nervous system, aids in pain relief and makes muscle activity easier. Caffeine is rapidly absorbed from the gastrointestinal tract, the maximum plasma concentration in adults is reached after 1 hour, the elimination half-life is 3 - 7 hours. Caffeine is metabolized in the liver and excreted in the urine.

INDICATIONS: Relieving pain in pain such as headache, migraine, sore throat, dysmenorrhea, pain after tooth extraction or dental procedures, toothache, muscle aches, tendons, traumatic pain , pain from arthritis, sinusitis, aches and pains caused by colds, flu.

CONTRAINDICATIONS: Hypersensitivity to any components of the drug. Patients with glucose deficiency - 6 - phosphate dehydrogenase.

Special precautions and warnings when using the drug:

For people with phenylceton-urinary and people must limit the amount of phenylalanine introduced into the body should avoid using Paracetamol with drugs or food containing Aspartam. For some people with hypersensitivity (asthma) Paracetamol should be avoided with medicines or sulfite-containing foods. Must be used with caution in patients with preexisting anemia, impaired liver and kidney function. Paracetamol may cause hepatotoxicity to the liver, so avoid or limit alcohol consumption.

When using high doses of caffeine can cause hypertension should be used with caution in patients with hypertension.

For Paracetamol-containing drugs: Physicians should warn patients for signs of serious skin reactions such as Steven-Johnson syndrome (SJS), toxic skin necrosis syndrome (TEN) or Lyell syndrome, Acute generalized pustular eruption (AGEP).

PREGNANT WOMEN AND LACTATION: Only use the medicine when absolutely necessary.

DRIVING AND OPERATION OF MACHINERY: The drug does not affect the ability to drive and operate machinery.

INTERACTIONS: Prolonged use of high doses of Paracetamol slightly enhances the anticoagulant effect of Coumarin and Indandion derivatives. Attention should be paid to the possibility of serious fever reduction in patients concurrently taking phenothiazine and hypothermia therapy. Anticonvulsants (Phenytoin, Barbiturate, Carbamazepin), Isoniazid increase the hepatotoxicity of Paracetamol. Excessive and prolonged alcohol consumption increases the hepatotoxicity of Paracetamol.

Avoid using them with medications or drinks with caffeine such as tea, coffee and some canned drinks. The elimination half-life of caffeine increases when combined with antibiotics: Ciprofloxacin, Enoxacin, Lomefloxacin, Norfloxacin, Ofloxacin. Do not combine caffeine with: Phenytoin, Fluvoxamine, Terbinafin, Cimetidine, Methoxsalen, oral contraceptives, Phenylpropanolamin, Ephedrine, Theophyllin.

ADVERSE EFFECTS: Paracetamol rarely causes side effects but sometimes causes allergy, skin rash, vomiting, nausea, in some cases can reduce overall blood cells, leukopenia, anemia. May cause hepatic failure (due to hepatolysis) when used in high doses and for a long time.

Regarding caffeine: when using high doses of caffeine can cause hypertension, drowsiness during the day. In addition, there are other undesirable effects: nausea, vomiting, diarrhea, insomnia, headache, tremor, nervousness, anxiety.

Inform your doctor unwanted effects encountered when using the drug.

OVERDOSE AND TREATMENT:

Paracetamol overdose: due to a single toxic dose or repeated large doses of Paracetamol (7.5 - 10 g daily, for 1-2 days) or due to long-term medication. Dose-dependent hepatic necrosis is the most acute acute toxic effect due to an overdose and can be fatal.

Symptoms of overdose include nausea, vomiting, abdominal pain, cyanosis on skin, mucosa, and nails.

Treatment:

When paracetamol poisoning is severe, aggressive supportive treatment is needed. Gastric lavage should be taken in all cases, preferably within 4 hours after ingestion.

The main detoxication therapy is the use of sulfhydryl compounds. N - acetylcysteine ​​has effect when taken orally or intravenously. Medication must be given immediately if it is less than 36 hours after taking Paracetamol. Treatment with N - acetylcysteine ​​is more effective when given for less than 10 hours after taking Paracetamol.

Alternatively, methionine, activated carbon and / or salt bleach may be used.

Caffeine overdose: rarely, overdose symptoms are often insomnia, restlessness, agitation and possibly delirium.

DOSAGE AND ADMINISTRATION: Adults and children over 12 years: take 1 to 4 times a day, take 1 or 2 capsules each time.

Do not take more than 8 tablets / day.

Minimum distance between 2 doses is 4 hours.

Or as directed by a physician.

Read the directions carefully before use.

Expiry date: 36 months from date of manufacture.

If you need further information, please consult your doctor.

Storage conditions: Store in dry places, not exceeding 30^oC, protect from light.

Standard: TCCS.