
Reduces the risk of arterial thrombotic events.
INGREDIENT COMPONENTS OF MEDICINE:
Clopidogrel (in the form of clopidogrel bisulfat) ........................ 75 mg
Excipients q.s ... .....................1 member
Manitol, microcrystallin cellulose M101, povidone K30, low - substituted hydroxypropyl cellulose (L-HPC (LH21)), hydrogenated castor oil, talc, hypromellose 2910 (6cp), hypromellose 2910 (15cp), polyethylene glycol 6000, titanium dioxide, iron oxide red).
DOSAGE FORM: Film-coated tablets.
PHARMACODYNAMIC:
ATC Code: B01AC04
Gavix, whose main active ingredient is clopidogrel, is a selective inhibitor of adenosine diphosphate (ADP) binding to its platelet receptor, thereby inhibiting ADP mediated activation of the glycoprotein GPIIb complex. / IIIa, thereby inhibiting platelet aggregation. The metabolism of clopidogrel is necessary for the inhibition of platelet aggregation. In addition to blocking the amplification of platelet activation from ADP release, clopidogrel also inhibits platelet aggregation due to synergies elsewhere. Clopidogrel acts by irreversibly altering platelet ADP receptors. Consequently, clopidogrel-attached platelets will affect the later stages of platelet life. The inhibition of platelet aggregation is dose-dependent, which can be seen after 2 hours of a single dose. Platelet aggregation and bleeding time returned to baseline values by hiccups, usually within 5 days after stopping treatment.
PHARMACOKINETICS: After repeated oral administration of 75 mg / day, clopidogrel is rapidly absorbed and metabolized primarily in the liver into two forms: active (thiol derivatives) and inactive (carboxylic acid derivatives) ). Thiol metabolites bind quickly and irreversibly to platelet ADP receptors. This metabolite is not detectable in plasma. Carboxylic acid derivatives account for 85% of the drug component circulating in plasma. The elimination half-life of the major circulating metabolite is 8 hours after single and repeated doses. About 50% of the drug is excreted in the urine and 46% in the feces for about 120 hours after dosing.
PRESENTATION: Box of 1 blister x 14 tablets.
POINT:
Reduces the risk of arterial thrombotic events in:
- Patients with myocardial infarction (from a few days to less than 35 days), ischemic stroke (from 7 days to less than 6 months) or established peripheral artery disease.
- Patients with acute coronary syndrome: Acute coronary syndrome with no ST segment elevation (unstable angina or non-Q-wave myocardial infarction) and acute myocardial infarction with ST segment swell, use aspirin in combination.
DOSAGE AND ADMINISTRATION:
Adults and elderly: 1 tablet (75 mg) / day. Can be taken with or without meals. No dosage adjustment is needed for the elderly or patients with kidney disease.
In patients with acute coronary syndrome with no ST segment elevation: first 4 tablets (300 mg), then continue at a dose of 75 mg / day (in combination with aspirin 75 - 325 mg) in subsequent days follow.
There are no data on the safety and efficacy of drugs for patients under 18 years of age.
CONTRAINDICATIONS: Hypersensitivity to the drug components. Bleeding due to active pathology such as gastroduodenal bleeding, retinal hemorrhage or intracranial. Severe liver failure
PRECAUTIONS: Patients at risk of bleeding due to trauma, surgery or other bleeding pathologies (such as ulcers). Discontinue the medicine 7 days before surgery. Stop taking the medicine when there is unusual bleeding (and tell the doctor right away).
Patients with renal insufficiency, liver disease.
Pregnant and lactating women:
Clopidogrel is not recommended during pregnancy because there are no adequate and well-controlled studies in pregnant women.
It is not known whether clopidogrel is excreted in human milk or not, so do not use the drug while breastfeeding.
Effects of drugs on work:
Clopidogrel does not affect machinery operators, train drivers, people working on high altitude and other cases.
INTERACTIONS: Precautions clopidogrel in combination with aspirin, nonsteroidal anti-inflammatory drugs, heparin, thrombolytic drugs. Clopidogrel and warfarin should not be used in combination.
ADVERSE EFFECTS: Gastrointestinal bleeding, intracranial hemorrhage, hematoma, epistaxis, haematuria, eye bleeding, abdominal pain, anorexia, diarrhea, constipation, vomiting, rash, itching.
Inform your doctor unwanted effects encountered when using the drug.
OVERDOSE AND TREATMENT:
No adverse effects have been reported following a single dose of 600 mg of clopidogrel. Bleeding time increased by 1.7 times compared with 75 mg / day dose. There is no antidote clopidogrel yet. Platelet transfusion may limit the effects of clopidogrel.
Read the directions carefully before use.
This drug is for a doctor's prescription.
SHELF LIFE: 36 months from date of manufacture.
STORAGE CONDITIONS:
Store in dry places, not exceeding 30oC, protect from light.
DATE OF CONSIDERATION OF AMENDMENTS AND UPDATED CONTENTS OF DRUGS GUIDANCE: November 7, 2017
Read the directions carefully before use.
Keep out of reach of CHILDREN.
Immediately inform your doctor or pharmacist of any unwanted effects encountered when using the drug.
This drug is for a doctor's prescription.
INGREDIENT, CONTENT OF MEDICINE:
Clopidogrel (as clopidogrel bisulfat) .................... 75 mg
Excipients q.s ... ................ 1 member
(Manitol, microcrystallin cellulose M101, povidone K30, low - substituted hydroxypropyl cellulose (L-HPC (LH21)), hydrogenated castor oil, talc, hypromellose 2910 (6cp), hypromellose 2910 (15cp), polyethylene glycol 6000, titanium dioxide, oxide red iron).
PRODUCT DESCRIPTION:
Film-coated tablets are light pink, one side is smooth, the other is heart-shaped, the sides and members are smooth.
PRESENTATION: Box of 1 blister x 14 tablets.
WHAT IS THE MEDICINE USED FOR:
Reduces the risk of arterial thrombotic events in:
- Patients with myocardial infarction (from a few days to less than 35 days), ischemic stroke (from 7 days to less than 6 months) or established peripheral artery disease.
- Patients with acute coronary syndrome: Acute coronary syndrome with no ST segment elevation (unstable angina or non-Q-wave myocardial infarction) and acute myocardial infarction with ST segment swell, use aspirin in combination.
HOW TO USE THIS MEDICINE AND DOSAGE:
Oral administration.
Adults and elderly: 1 tablet (75 mg) / day. Can be taken with or without meals. No dosage adjustment is needed for the elderly or patients with kidney disease.
In patients with acute coronary syndrome with no ST segment elevation: first 4 tablets (300 mg), then continue at 75 mg / day (in combination with aspirin 75-325 mg) in subsequent days follow.
There are no data on the safety and efficacy of drugs for patients under 18 years of age.
Or as directed by a physician.
WHEN SHOULD NOT TAKE THIS MEDICINE:
Hypersensitivity to the drug component. Bleeding due to active pathology such as gastroduodenal bleeding, or retinal hemorrhage
intracranial.
Severe liver failure
UNWANTED EFFECTS:
Gastrointestinal bleeding, intracranial hemorrhage, hematoma, epistaxis, haematuria, eye bleeding, abdominal pain, anorexia, diarrhea, constipation, vomiting, rash, itching.
Immediately inform your doctor or pharmacist of any unwanted effects encountered when using the drug.
WHAT DRUGS OR FOOD AVOIDES AVOID TO AVOID WHEN USING THIS MEDICINE:
Use caution when using clopidogrel in combination with aspirin, nonsteroidal anti-inflammatory drugs, heparin, thrombolytic drugs.
Clopidogrel and warfarin should not be used in combination.
What to do when you forget to use drugs:
Take the next dose as directed. Do not use extra medicine to make up the missed dose to avoid overdose.
HOW TO STORAGE THIS MEDICINE:
Store in dry places, not exceeding 30oC, protect from light.
SIGNS AND SYMPTOMS WHEN USING OVERDOSE DRUGS: No side effects have been reported after a single dose of 600 mg of clopidogrel. Bleeding time increased by 1.7 times compared with 75 mg / day dose.
WHAT TO DO WHEN USING DRUGS TOO MUCH RECOMMENDED: There is no antidote clopidogrel. Platelet transfusion may limit the effects of clopidogrel.
IMPORTANT THINGS WHEN USING THIS MEDICINE:
Patients at risk of bleeding from trauma, surgery or other bleeding pathologies (such as ulcers). Discontinue the medicine 7 days before surgery. Stop taking the medicine when there is unusual bleeding and notify the doctor immediately.
Patients with renal insufficiency, liver disease.
Pregnant and lactating women: Clopidogrel is not recommended during pregnancy because there are no adequate and well-controlled studies in pregnant women.
It is not known whether clopidogrel is excreted in human milk or not, so do not use the drug while breastfeeding.
Effects of drugs on work: Clopidogrel has no effect on machine operators, driving trains, people working on high altitude and other cases.
WHEN TO CONSULT DOCTOR AND PHARMACY:
If you need further information, please consult your doctor or pharmacist.
SHELF-LIFE OF MEDICINE: 36 months from date of manufacture.
DATE OF CONSIDERATION OF AMENDMENTS AND UPDATED CONTENTS OF DRUGS GUIDANCE: November 7, 2017
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