Primary hypertension for uncontrolled blood pressure subjects with monotherapy.
RECIPE:
Perindopril erbumin .................................. 4 mg
Indapamid ........................... 1.25 mg
Excipients 1 capsule
(Lactose, avicel, PVP K30, sodium starch glycolate, magnesium stearate).
DOSAGE FORM: Tablets.
PRESENTATION: Box of 1 blister x 30 tablets.
PHARMACODYNAMIC:
Perindopril is an angiotensin converting enzyme inhibitor (ACE: Angiotensin Converting Enzyme), acting through the activity of perindoprilat metabolite. Perindopril prevents angiotensin I from converting into angiotensin II, a potent vasoconstrictor. ACE inhibitors reduce angiotensin II in plasma, leading to increased renin activity in plasma and lead to decreased secretion of aldosteron, so reduce sodium retention and increase potassium retention in the body. Because ACE inactivates bradykinin, ACE inhibition also leads to increased activity of the local Kallikrein-Kinin system in the circulation and thus activates the prostaglandin system, which also contributes to lower blood pressure. In hypertension, perindopril reduces blood pressure by reducing systemic peripheral resistance. The drug usually causes varicose veins and possibly veins.
Indapamide is a diuretic sulfonamide. Indapamide has a diuretic and anti-hypertensive effect. The drug inhibits the reabsorption of sodium ions in the diluted section of the distal tubule, increases sodium and chloride secretion, thereby increasing diuresis. Indapamide causes the vessel's response to vasoconstrictor amines to return to normal, reducing peripheral small artery resistance. The drug maintains its antihypertensive effect in patients with no renal function.
PHARMACOKINETICS: The drug is rapidly absorbed after oral administration. The drug is strongly metabolized, mainly in the liver. Perindopril is converted into active perindoprilat, food reduces the biotransformation into perindoprilat and thereby reduces bioavailability. The drug is eliminated mainly through urine. Hemodialysis does not remove indapamide from the circulation.
INDICATIONS: Primary hypertension for subjects with uncontrolled blood pressure with monotherapy.
CONTRAINDICATIONS:
Hypersensitivity to perindopril, indapamide and sulfonamide derivatives.
People with a history of angioedema have been linked to ACE inhibitors. New patients with stroke, anuria. Patients with severe renal impairment (creatinine clearance <30 ml / min)
Because there are no studies in children, it is currently contraindicated for children.
PRECAUTIONS: Regarding perindopril: Caution should be exercised when administering the drug to patients with the following risks: In case of heart failure, dehydration, risk of hypotension and / or renal failure, renal artery stenosis. Hemodialysis patients, renal insufficiency, renal vascular hypertension, congestive heart failure, patients undergoing surgery, diabetes, stable angina. Elderly.
Related to indapamide: Caution should be used in patients with severe renal disease, patients with impaired liver function or progressive liver disease, patients with hyperparathyroidism or thyroid conditions, patients with surgery Cut off sympathetic nerves. Periodically determine blood glucose levels, especially in patients who have or suspected diabetes.
PREGNANT WOMEN AND LACTATION:
Do not use the drug for pregnant and lactating women.
DRIVING AND OPERATING MACHINERY:
Use with caution because the drug can cause headaches, dizziness.
DRUG INTERACTIONS:
Nonsteroidal anti-inflammatory drugs, corticosteroids, tetracosactide reduce the effect of perindopril. The antihypertensive effect of perindopril may become excessive when a previous diuretic is used. Combination with sedatives and antidepressants imipramine will increase the risk of orthostatic hypotension. Perindopril increases the hypoglycemic effect of insulin and oral hypoglycemic agents. Combining perindopril with diuretics to keep potassium and potassium salts at risk of hyperkalemia, especially in renal failure. The combination of lithium and perindopril increases blood lithium.
Do not combine Indapamide with other diuretics because it can cause hypokalemia and hyperuricemia. Do not use with lithium because of the risk of lithium toxicity. Indapamide reduces the arterial response to vasoconstrictors such as noradrenalin, but not enough to prevent noradrenalin.
UNWANTED EFFECTS:
Perindopril-related: headache, mood disorders and / or sleep, weakness; taste disorders, dizziness, cramps; skin rash; dry cough type of irritation; impotence, dry mouth; slightly reduced hemoglobin; hyperkalemia; angioedema of the face, extremities, lips, tongue, glottis and / or larynx.
Associated with indapamide: fluid electrolyte disturbance, hypokalemia, hyponatremia or alkalosis due to hypochloremia; fatigue, muscle weakness; headache, dizziness, dizziness; loss of appetite, nausea, vomiting; Orthostatic hypotension, palpitations; rash, rashes, urticaria; thrombocytopenia, agranulocytosis; acute myopia, cramps.
Inform your doctor unwanted effects encountered when using the drug.
OVERDOSE AND TREATMENT:
Related to indapamide: Symptoms: Electrolyte disorders, hypotension, muscle weakness, digestive disorders, nausea, vomiting, respiratory failure. Treatment of overdose is symptomatic treatment, there is no specific antidote. If acute overdose, conduct gastric lavage or induce vomiting, carefully assess water and electrolytes afterwards. Treatment support maintenance of respiratory and circulatory function.
Related to perindopril: Symptoms associated with hypotension. Treatment: Wash the stomach and establish an intravenous line immediately to give isotonic saline solution. Conducting dialysis (70 ml / min) can remove perindopril from the blood.
DOSAGE AND ADMINISTRATION: Coperil Plus is usually given once in the morning, before meals.
Dose in hypertension: 1 Coperil Plus tablet daily (perindopril 4 mg / indapamid 1.25 mg).
Renal impairment: Creatinine clearance> 60 ml / min: No dose adjustment is necessary; creatinine clearance from 30 to 60 ml / min: Start with a dose corresponding to each component of the combination form that the patient tolerates (the recommended dose perindopril is 2 mg / day), it is not recommended to split tablets. Coperil Plus drug, so should find another suitable dosage form.
For elderly patients: The starting dose needs to be adjusted depending on the response of blood pressure, especially when there is a loss of salt and water, to avoid the sudden onset of hypotension.
Or as directed by a physician.
Read the directions carefully before use.
If you need further information, please consult your doctor.
This drug is for a doctor's prescription.
Expiry date: 36 months from date of manufacture.
Storage conditions: Store in dry places, not exceeding 30oC, protect from light.
Standard: TCCS.
Treatment of hypertension, especially in patients with metabolic complications such as diabetes. Treatment of chronic stable angina, coronary angina.
Atorlip is used in the following cases: increased total cholesterol, increased LDL-cholesterol, increased triglycerides.
Atorlip is used in the following cases: increased total cholesterol, increased LDL-cholesterol, increased triglycerides.
Treatment of type 2 diabetes is aimed at controlling blood sugar levels, combined with diet and exercise.
