CIFGA

RECIPE:

Ciprofloxacin .............................. 500 mg

Excipients 1 capsule

(Cassava starch, sodium starch glycolate, ludipress, magnesium stearate, PVP K30, HPMC, PEG 6000, titanium dioxide, talc).

DOSAGE FORM: Film coated tablet.

PRESENTATION: Box of 2 blisters x 10 tablets.

PHARMACOKINETICS: Cifga with the main active ingredient is ciprofloxacin, semi-synthetic antibiotic, has broad antibacterial spectrum, belongs to quinolon group, also known as DNA girase inhibitors. By inhibiting the DNA girase enzyme, the drug prevents the replication of chromosomes, preventing bacteria from reproducing quickly. Ciprofloxacin works well with bacteria resistant to antibiotics of other groups (aminoglycosides, cephalosporins, tetracycline, penicillins, ...) and is considered one of the most powerful drugs in the fluoroquinolon group.

PHARMACOKINETICS: Ciprofloxacin is rapidly and easily absorbed from the gastrointestinal tract. With food and antacids, absorption is slowed but not significantly affected. After oral administration, the maximum concentration of ciprofloxacin in the blood appears after 1-2 hours with absolute bioavailability of 70-80%. Plasma half-life is 3.5 - 4.5 hours in patients with normal renal function, this time is longer in patients with renal failure and in the elderly. Ciprofloxacin is widely distributed and has high concentrations in infected areas (body fluids, tissues), in general, it is easily absorbed into tissues, including cerebrospinal fluid. Ciprofloxacin crosses the placenta and is secreted in breast milk, with relatively high concentrations in bile, mainly excreted by the kidneys.

INDICATIONS: Treatment of prostatitis, osteomyelitis, severe bacterial enterocolitis, septicemia.

Urinary tract infections are not complicated

Because fluoroquinolones, including ciprofloxacin, are associated with serious adverse reactions (see Warnings and cautions) and uncomplicated urinary tract infections in some patients who may resolve on their own, they should only be used. ciprofloxacin for patients who have no alternative treatment options.

Exacerbation of bacterial infections of chronic bronchitis

Due to fluoroquinolone antibiotics, including ciprofloxacin, associated with serious adverse reactions (see Warnings and cautions) and acute bacterial infections of chronic bronchitis in some patients may resolve on their own, should only be Use ciprofloxacin for patients who have no other alternative treatment options.

Acute sinusitis caused by bacteria

Because fluoroquinolones, including ciprofloxacin, are associated with serious adverse reactions (see Warnings and cautions) and acute bacterial sinusitis in some patients may resolve, ciprofloxacin should be used only. for patients who have no alternative treatment options.

CONTRAINDICATIONS: Hypersensitivity to ciprofloxacin or other quinolones.

WARNING AND PRECAUTIONS:

Serious adverse reactions are likely to be irreversible and cause disability, including tendonitis, tendon rupture, peripheral neuropathy and adverse central nervous system effects.

Fluoroquinolone antibiotics have been associated with serious and potentially irreversible adverse reactions on the various organ systems of the body. These reactions may occur simultaneously on the same patient. The most commonly reported adverse reactions include tendonitis, tendon rupture, arthralgia, myalgia, peripheral neuropathy, and adverse effects on the central nervous system (hallucinations, anxiety, depression). , insomnia, severe headache and confusion). These reactions can occur within hours to weeks after using the medication. Patients of any age or without pre-existing risk factors may experience the above adverse reactions.

Stop using the medicine at the first sign or symptom of any serious adverse reaction. In addition, avoid using fluoroquinolone antibiotics for patients who have experienced severe fluoroquinolon-related reactions.

Ciprofloxacin should be used with caution in people with a history of seizures or central nervous system disorders, people with impaired hepatic or renal function, people with glucose-6-phosphate dehydrogenase deficiency, and people with myasthenia gravis. Long-term use of ciprofloxacin can cause bacteria not sensitive to the drug, to monitor patients and to make regular antibiotics for appropriate treatment with antibiotics.

Ciprofloxacin can make the tests for Mycobacterium tuberculosis negative. Limit ciprofloxacin to children and adolescents who are growing.

Pregnant women and breastfeeding: Ciprofloxacin should only be used in pregnancy in severe infections without alternative antibiotics, requiring fluoroquinolones. Do not give ciprofloxacin to nursing mothers, because ciprofloxacin accumulates in the milk and can reach concentrations that may harm a baby. If mother is forced to use ciprofloxacin, then must stop breastfeeding.

DRIVING AND OPERATION OF MACHINERY: Caution when driving and operating machinery because it may cause dizziness or lightheadedness.

INTERACTIONS: Concurrent use of nonsteroidal anti-inflammatory drugs (ibuprofen, indomethacin, ...) will increase the side effects of ciprofloxacin. Concomitant use of aluminum and magnesium antacids reduces serum concentration and bioavailability of ciprofloxacin. Ciprofloxacin should not be taken at the same time with antacid drugs, medication should be taken apart (anti-acidic drugs should be taken 2-4 hours before taking ciprofloxacin). Absorption of ciprofloxacin may be halved if taken concurrently with some cytotoxic drugs (cyclophosphamid, vincristin, doxorubicin, cytosin arabinosid, mitozantron). Concomitant use didanosin, ciprofloxacin concentration was significantly reduced. Ciprofloxacin should be taken 2 hours before didanosin or 6 hours after didanosin. Iron preparations (fumarate, gluconate, sulfate) or zinc significantly reduce the absorption of ciprofloxacin in the intestine, zinc-influenced preparations have less effect. Avoid concomitant use of ciprofloxacin with iron or zinc preparations or drink as far apart as possible. Sucralfate reduces the absorption of ciprofloxacin. Antibiotics should be given 2-6 hours before taking sucralfate. Ciprofloxacin increases theophylline serum concentration when taken concomitantly, causing theophylin's side effects. Theophylin blood levels need to be checked and theophylin dose can be reduced if two medications are required. Ciprofloxacin and ciclosporin concomitantly may cause a temporary increase in serum creatinine. Blood creatinine should be checked 2 times per week. Probenecid reduces glomerular filtration rate and reduces tubular secretion, thus reducing drug excretion in the urine. Ciprofloxacin increases warfarin activity when combined. Need to check blood prothrombin regularly and adjust anticoagulant dose.

UNWANTED EFFECTS:

Common: Nausea, vomiting, diarrhea, abdominal pain. Temporarily increase the concentration of transaminases.

Uncommon: Headache, drug fever, eosinophilia, anemia, thrombocytopenia. Fast heart beat. Rash, itching, superficial phlebitis. Pain in joints, swelling of joints.

Rarely: Anaphylactic reaction or anaphylactic form. Hemolytic anemia, leukocytosis, thrombocytopenia, changes in prothrombin levels, insomnia, depression. Disorders of vision, hearing, taste and smell. Pseudomembranous colitis. Skin - mucosal syndrome, Lyell's syndrome, skin rash. Hepatitis, cholestatic jaundice. Myalgia, tendonitis (heel tendon) and surrounding tissue. Renal failure, interstitial nephritis. Hypersensitivity to light when exposed to the sun, shortness of breath, bronchospasm.

Inform your doctor unwanted effects encountered when using the drug.

OVERDOSE AND TREATMENT: If a large dose has been taken, it is necessary to consider the following measures: Inducing vomiting, gastric lavage, diuretic. Careful monitoring of patients is needed and supportive treatment, such as adequate fluid replacement.

DOSAGE AND ADMINISTRATION: Drink plenty of water during the medication. Take the medicine 2 hours after a meal.

Adults: Take 500 mg / time, 2 times a day, for 7-14 days.

Acute urinary tract infections are not complicated: 250 mg / time, 2 times a day, for 3 days.

Acute sinus tablets: 500 mg / time, 2 times a day, for 10 days.

Or as directed by a physician.

Read the directions carefully before use.

Expiry date: 36 months from date of manufacture.

If you need further information, please consult your doctor.

Storage conditions: Store in dry places, not exceeding 30^oC, protect from light.

This drug is for a doctor's prescription.

Standard: TCCS.