Atorlip is used in the following cases: increased total cholesterol, increased LDL-cholesterol, increased triglycerides.
RECIPE:
Atorvastatin calcium ... ........... 10 mg
Excipients q.s ... ..................... 1 member
(Avicel, lactose, yellow tartrazine lake, sodium starch glycolate, PVP K30, magnesium stearate).
DOSAGE FORM: Tablets.
PRESENTATION: Box of 3 blisters x 10 tablets.
NATURE:
Atorlip is a synthetic lipid-lowering drug, with the active ingredient is atorvastatin calcium, which inhibits the competitive competition of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, blocking HMG- CoA into mevalonat, a precursor of cholesterol. Atorvastatin reduces lipoprotein and plasma cholesterol by inhibiting the synthesis of cholesterol in the liver and by increasing the number of LDL (low density lipoprotein) receptors in the liver on the cell surface, thereby increasing its removal and degradation. LDL variable.
Atorvastatin reduces the most LDL cholesterol (25 - 61%) compared to any drug used alone, and proved to be promising for patients who need to reduce cholesterol a lot, which is currently only achieved when the drug combination. Atorvastatin raises the level of HDL (high density lipoprotein) cholesterol by 5 - 15% and thus lowers the ratio of LDL / HDL and total cholesterol / HDL. Atorvastatin also reduces plasma triglycerides by 10 - 30% by increasing clearance of VLDL (very low density lipoprotein) by LDL receptor.
In clinical studies, the evidence suggests that statins significantly reduce coronary events, all cardiovascular events and reduce the total number of deaths in people with coronary artery disease.
Atorvastatin is rapidly absorbed after oral administration, the maximum concentration of drug in plasma is reached within 1-2 hours. The rate of absorption and atorvastatin concentration increases in proportion to the oral dose. Although food reduces the rate and extent of absorption of the drug, the therapeutic effect is unchanged when atorvastatin is taken orally with food. Atorvastatin plasma concentration after evening drug use is lower than in the morning. However, the effect is the same regardless of the time of day.
POINT:
Atorlip is used in the following cases: increased total cholesterol, increased LDL-cholesterol, increased triglycerides.
Slows the progression of coronary atherosclerosis.
Primary prevention of coronary events in patients with hypercholesterolemia: reduces the risk of myocardial infarction, reduces the risk of coronary regeneration procedures, reduces the risk of death from cardiovascular disease.
CONTRAINDICATIONS:
Hypersensitivity to the drug.
Active liver disease, persistent elevation of serum transaminases and exceeding 3 times the upper limit of normal
Pregnant or suspected pregnant women or nursing women.
CAREFUL:
Before starting statin therapy, it is necessary to identify the cause of hypercholesterolemia and quantify lipid indicators to determine the therapeutic dose. Lipid measurements should be performed periodically, at intervals not less than 4 weeks, and adjusted in accordance with the patient's response to the medication.
Caution should be used in patients who consume a lot of alcohol and / or have a history of liver disease. Liver function tests should be performed before starting treatment and during use.
Statin therapy has the potential to cause myositis and rhabdomyolysis, so the dose should be reduced or discontinued in patients with conditions suggestive of myositis (myalgia, muscle weakness, increased creatine phosphokinase by more than 10). times above the upper limit of normal) or there are risk factors for the development of secondary renal failure into paroxysmal myoglobulinuria.
DRUG INTERACTIONS:
Combined treatment of atorvastatin with cyclosporin, gemfibrozil, erythromycin, itraconazole, ketoconazole, niacin increases the risk of myositis and rhabdomyolysis.
Atorvastatin enhances the effect of warfarin.
Antacids, cholestyramine reduce the concentration of atorvastatin in plasma.
UNWANTED EFFECTS:
Usually mild and transient: constipation, flatulence, indigestion, abdominal pain, headache, nausea, muscle aches, fatigue, diarrhea, insomnia.
Inform your doctor unwanted effects encountered when using the drug.
OVERDOSE AND TREATMENT:
There is no specific treatment when overdosing Atorvastatin. If overdose proceed to symptomatic treatment and necessary supportive measures. Due to the strong binding of plasma proteins, there is no hope to significantly increase Atorvastatin clearance by hemodialysis.
DOSAGE AND ADMINISTRATION:
Patients should have a reasonable diet before treatment with Atorlip and should maintain this diet during treatment.
The drug can be taken at any time of the day and does not depend on the meal.
Initial dose: 10 - 20 mg once daily.
Patients who need to lower LDL-cholesterol (more than 45%) may start with a dose of 40 mg once daily.
Treatment dose: 10 - 80 mg once daily, the dose is adjusted according to the results of testing of lipid index.
Or as directed by a physician.
Read the directions carefully before use.
If you need further information, please consult your doctor.
This drug is for a doctor's prescription.
Expiry date: 36 months from date of manufacture.
Storage conditions: Store in dry places, not exceeding 30oC.
Standard: TCCS.
Product packaging: 30
Treatment of hypertension, especially in patients with metabolic complications such as diabetes. Treatment of chronic stable angina, coronary angina.
Atorlip is used in the following cases: increased total cholesterol, increased LDL-cholesterol, increased triglycerides.
Treatment of type 2 diabetes is aimed at controlling blood sugar levels, combined with diet and exercise.
Primary hypertension for uncontrolled blood pressure subjects with monotherapy.
