Treatment of hypertension, especially in patients with metabolic complications such as diabetes. Treatment of chronic stable angina, coronary angina.
RECIPE:
Amlodipine besilate, calculated according to Amlodipine .................................... 5mg
Excipients q.s ... ....................... 1 member
(Avicel, dicalci phosphate dihydrate, PVP K30, sodium lauryl sulfate, sodium starch glycolate, aerosil, magnesium stearate).
DOSAGE FORM: Hard capsule.
PRESENTATION: Box of 3 blisters x 10 tablets.
PHARMACOKINETICS: Apitim with active ingredient Amlodipine is a calcium antagonist belonging to dihydropyridine group. It inhibits the flow of calcium through the membrane into myocardial and smooth muscle cells of the vascular wall by blocking the slow calcium channels of the cell membrane. Thanks to the effect of the drug, the smooth muscle tone of the blood vessels decreases, thereby reducing the peripheral resistance leading to hypotension.
Apitim fights angina mainly due to dilatation of peripheral arterioles and reduction of cardiac afterload. Myocardial energy consumption and oxygen demand decreased because the drug did not cause tachycardia reflex. Amlodipine dilates coronary arteries (arteries and arterioles) in both normal and anemic areas leading to increased oxygen supply to the heart muscle.
PHARMACOKINETICS: The bioavailability of Amlodipine when taken is about 60 - 80% and is not affected by food. The elimination half-life is 30-40 hours. Stable concentrations in plasma achieved 7-8 days after once a day medication. The volume of distribution is approximately 21 liters / kg body weight and the protein - plasma binding drug is high (over 98%). The drug is mainly metabolized by the liver. Inactive metabolites and excreted in the urine. In patients with hepatic impairment, reduce the dose or prolong the time between doses.
INDICATIONS: Treatment of hypertension, especially in patients with metabolic complications such as diabetes.
Treatment of chronic stable angina, coronary angina.
CONTRAINDICATIONS: Hypersensitivity to dihydropyridine derivatives. Not recommended for people with heart failure who have not been treated stably.
PRECAUTIONS: Impaired liver function, aortic stenosis, heart failure after acute myocardial infarction.
PREGNANT WOMEN AND LACTATION: Calcium channel blockers can inhibit early uterine contractions. However, the drug has no adverse effects during childbirth. The risk of hypoxia to the fetus should be taken into account if the mother lowers blood pressure. In experimental animals, calcium channel blockers can cause teratogenicity in the form of bone defects. Therefore, avoid Amlodipine for pregnant women, especially in the first 3 months of pregnancy.
There have been no reports assessing the accumulation of Amlodipine in breast milk; Therefore, you should consult your doctor when using the drug during breastfeeding.
DRIVING AND OPERATION OF MACHINES: There are no documents on the effect of drugs on the ability to drive and operate machines. However, caution should be exercised because, like other hypertension medications, it can cause dizziness and dizziness.
INTERACTIONS: Anesthetics increase the effect of Amlodipine and may cause blood pressure to drop more sharply. Taking lithium with Amlodipine can cause neurotoxicity, nausea, vomiting, and diarrhea. Nonsteroidal anti-inflammatory drugs, especially indomethacin, may reduce the effect of Amlodipine. Use caution with drugs that are highly bound to plasma proteins (such as coumarin derivatives, hydantoin ...) with Amlodipine because Amlodipine is also highly protein bound, so the concentrations of these drugs in a free (unbound) form are may change in serum.
UNWANTED EFFECTS:
Common: Ankle edema (dose related), headache, dizziness, flushing and feeling hot, tired, weak, palpitations, cramps, nausea, abdominal pain, indigestion , shortness of breath.
Uncommon: Excessive hypotension, tachycardia, chest pain, rash, itching, myalgia, arthralgia, sleep disorders.
Rarely: extrasystole, hyperplasia, hives, increased liver enzymes, hyperglycemia, confusion, erythema multiforme.
Inform your doctor unwanted effects encountered when using the drug.
OVERDOSE AND TREATMENT: Amlodipine poisoning is very rare.
Treatment: Monitor the heart by using an electrocardiogram and symptomatic treatment of cardiovascular effects with gastric lavage and activated charcoal. If you need to adjust the electrolytes. In case of bradycardia and heart block, intravenous atropine must be injected, intravenous drip of calcium gluconate, isoprenalin or adrenalin or dopamine. For patients with reduced circulating volume, infusion of 0.9% sodium chloride solution is required. When a pacemaker is needed. In case of severe hypotension, intravenous injection of 0.9% sodium chloride solution, adrenalin. If this does not work, use isoprenalin in combination with amrinone.
DOSAGE AND ADMINISTRATION:
Depending on the response of each patient.
Initial dose: Take 5 mg once daily, then increase gradually. May increase the dose to 10 mg once daily.
No dose adjustment is required when combined with thiazide diuretics, beta-blockers or ACE inhibitors.
Or as directed by a physician.
Read the directions carefully before use.
Expiry date: 36 months from date of manufacture.
If you need further information, please consult your doctor.
Storage conditions: Store in dry places, not exceeding 30oC, protect from light.
This drug is for a doctor's prescription.
Standard: TCCS.
Product packaging: 30
Atorlip is used in the following cases: increased total cholesterol, increased LDL-cholesterol, increased triglycerides.
Atorlip is used in the following cases: increased total cholesterol, increased LDL-cholesterol, increased triglycerides.
Treatment of type 2 diabetes is aimed at controlling blood sugar levels, combined with diet and exercise.
Primary hypertension for uncontrolled blood pressure subjects with monotherapy.
